Yuga,
I have not looked into the forum for quite long time. Just now saw ur message.
Generally even though we access applications with singe URL, it will be mapped with more than one server (if system has more than one). I hope u know that application can be accessed via IP address which provides access, only to that server.
Whenever i faced this problem, i used to access the application using IP address (in my case 2 servers) and then edit screen sets and finish it. (in both servers)
If its still not working, we will restart those servers and try after some 10 mins ( dont ask me why after 10 mins, simply we wait
)
After that it always used to work fine. If those steps did not work, then i would have tried by deleting and then configure it from the scratch. ( which is my 3rd option)
Thanks,
-neoandr